This experiment was designed to determine whether a preparation of Pueraria mirifica Airy Shaw and Suvatabandhu, a phytoestrogens containing herb, can protect vascular functions and bone turnover in ovariectomized rats. Thirty two female Wistar albino rats were randomly assigned into 4 groups. Group 1, 2 and 3 were undergone bilateral ovariectomy and orally administered with P. mirifica 100 mg/kg/day (OVX+P. mirifica), subcutaneously injected of estradiol valerate 300 ug/kg/week (OVX+Estrogen) and distilled water fed (OVX), respectively. Group 4 was sham operated and treated with distilled water (Sham). Compared to the OVX group, treatment with P. mirifica resulted in significantly increased in NO production. The P. mirifica and estrogen treatment groups significantly increased in relative dry weight, ash weight of right femurs. Bone degenerative found in microscopic examinations and ALP level were also decreased comparing with the OVX group. These results indicate that treatment with the P. mirifica preparation preserves endothelial vasodilator function and bone structures in ovariectomized rats.
Author: Chenphop Sawangmake
Imprint: Bangkok: Chulalongkorn University, 2006
Pages: 99 p
Dissertation: Thesis (M.Sc.) –Chulalongkorn University, 2006
# # 4875551731: MAJOR VETERINARY PHARMACOLOGY
KEY WORDS: PUERARIA MIRIFICA / THORACIC AORTA / BONE / OVARIECTOMIZED RAT
CHENPHOP SAWANGMAKE: EFFECTS OF PUERARIA MIRIFICA EXTRACT ON FUNCTIONS AND PATHOGENICITIES OF THORACIC AORTA AND BONE IN OVARIECTOMIZED RATS. THESIS ADVISOR: ASSOC. PROF. SUPATRA SRICHAIRAT, Ph.D., THESIS COADVISOR: ASST. PROF. SOMLAK
POUNGSHOMPOO, D.V.M., 99 pp.
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