This study aimed to investigate the effects of three-month administration of crude of Pueraria mirifica, a Thai phytoestrogen containing plant, on bone loss and reproductive organs in the late middle age (7 months old) ovariectomized (OVX) and orchidectomized (ORX) rats.
After three months, rats were sacrificed and the bone mineral density (BMD) and bone mineral content (BMC) at the tibia, femur and the 4lh lumbar vertebral body were measured with a peripheral quantitative computerized tomography (pQCT) densitometry and the bone microarchitecture was determined by histological technique.
Bone loss in trabecular and cortical compartments at the various sites in axial bone (fourth lumbar vertebral body) and long bones (tibia and femur) induced by OVX in female rats or ORX in male rats was dose—dependently prevented by P. mirifica. The effects of 100 mg/kg BW/day of P. mirifica treatment on prevention of bone loss were equivalent to those of 0.1 mg/kg BW/day of EE.
These results suggest that P. mirifica has a therapeutic potential as a drug for treatment or prevention of osteoporosis in elderly women and elderly men with hypogonadism.
Author: Nontakorn Urasopon
Imprint: Bangkok: Chulalongkorn University, 2007
Pages: 146 p
Dissertation: Thesis (Ph.D.)—-Chu|a|ongkorn University, 2007
## 4573862223: Major Biological Science *
KEYWORDS: Bone Gonadectomy Phytoestrogens Pueraria mirifica Rat.
NONTAKORN URASOPON: EFFECTS OF WHITE KWAO KRUA Pueraria mirifica Airy Shaw & Suvatabandhu ON BONE LOSS IN GONADECTOMIZED RATS. THESIS ADVISOR: ASSOC. PROF. SUCHINDA MALAIVIJITNOND, Ph.D., THESIS CO-ADVISOR: ASSOC. PROF. YUZURU HAMADA, Ph.D., 146 pp.
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