For more than 500 years, people in South East Asia have been using the tuberous root of “Pueraria mirifica (PM) or White Kwao Krua” for its useful anti-aging properties. It belongs to the family Leguminosae, subfamily Papilionoideae or the soy, bean subfamily. The mean of name mirifica in Latin it means miracle. PM is most popular in Thailand, China and Japan as shown in Figure 1, owing to the referent for Thai natural product over chemical ones. The isolation and identification of estrogen from the root of PM benefits are attributed to the plants generous content of phytoestrogen, including miroestrol and deoxymiroestrol which are believed to exert particularly positive effects being similar in chemical structure to human estriol, a female estrogen. Various active ingredients such as miroestrol, deoxymiroestrol, daidzein, genistin, genistein, B-Sitosterol, stigmasterol, cournestrol, pueraria, campesterol, mirificournestan, kwakhurin, and mirificine are obtained from PM (Figure. 2). It has been widely used as health product for improving skin tones and muscle firmness, reducing stress, maintaining a youthful look as an anti-aging herbal food dietary supplement, improving circulation, as an effective natural herbal remedy for menopausal, prostate problems, and revitalizing human cells by replenishing depleting hormones. It is used for like antioxidative activity, aging skin, breast enlargement, anti-wrinkle agent, sagging breasts, wrinkled skin and gray hair care product in cosmetic products. PM in the form of crude extract has been introduced just recently. With modern extraction technology, the extract from dried tuber roots is standardized and prepared in the form of powder and solution. The extract solution is used in cosmetic and cosmaceutical industry such as preparation of breast cream, eye gel and skin moisturizer. However, the development of PM on the moisturizing gel for anti-aging is not reported.
Therefore, the purpose of this study was to formulate a moisturizing gel that consisting of PM extract for anti-wrinkle agent for anti-aging product in woman.
In conclusion, The PM extract could be used for the moisturizing gel formulation owing to the stability of three formulations did not change after storage in accelerate conditions. Formula II exhibited the appropriate formulation for moisturizing enhancement of skin providing a good moisturizing, quick absorption and not skin irritated. Hence, the formulation of moisturizing gel containing PM extract as an anti-aging was achieved.
Thanachod Thammachatl1, Sompoch Tubcharoenl1, Sitthiphong Soradech3 and Somnuk Promdang2
1National Swine Research and Training Center, Suwanvajokkasikit Animal Research and Development Institute (SARDI), Kasetsart University, Kampheangsaen, Nakorn pathom 73140, Thailand
2Phytochemistry Research and Analysis Unit, Central Laboratory and Greenhouse Complex, Kasetsart University, Kampheangsaen, Nakorn pathom 73140, Thailand
3Pharmaceutical and Natural products Department, Thailand of Scientific and Technological Research (TISTR), Technopolis, Klong 5, Klong Luang, Pathumthani 12120, Thailand
KEYWORDS: Gel, Pueraria mirifica, Formulation, Cosmeceutical, phytochemistry
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